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Med Die
Terra med Alliance News Risk Of Leukemia With Multiple Sclerosis Drug Higher Than Thought
Terra med Alliance News: Mitoxantrone is an immunosuppressant drug approved by the FDA for treatment of several forms of advancing MS. It is one of only two drugs that has been shown to benefit people with secondary progressive MS who are having attacks. However, the drug can cause heart damage at high total doses. Due to this, the lifetime cumulative dose is equal to about eight to 12 doses over two to three years.
Previous studies have also shown that the people with MS treated with the drug have an increased risk of developing leukemia. Those studies showed that acute leukemia occurred in .07 percent to .25 percent of MS patients taking mitoxantrone. Today's retrospective study of 2,854 Italian people with MS receiving the drug found that leukemia occurred in .74 percent.
"This rate is significantly higher than what has been previously reported," said study author Vittorio Martinelli, MD, of University Vita-Salute in Milan, Italy. "The potential risk of leukemia should be carefully considered against the potential benefits of mitoxantrone treatment on every single patient."
The study participants all had at least one cycle of mitoxantrone treatment and were observed for at least one year. A total of 21 people developed leukemia, eight of whom died. The people who developed leukemia had more treatment cycles than those who did not develop leukemia—8.6 cycles versus 7.2 cycles. They also had a greater cumulative dose of mitoxantrone.
The leukemia occurred an average of three years after the first use of the drug and an average of 18 months after the end of treatment.
"It is vital that all MS patients treated with mitoxantrone undergo prolonged and careful hematological follow-up to check for acute leukemia," Martinelli said.
The American Cancer Society has estimated there were 44,270 new cases of leukemia in the general U.S. population last year. Adapted from materials provided by American Academy of Neurology.
Terra med Alliance is a non-profit organization in the battle against leukemia helps children living with cancer and their families. Our goal is to make sure children battling cancer know they are not alone. For more information please visit www.terramedalliance.org. Email at contact@terramedalliance.org
About the Author
Terra med Alliance is a non-profit organization in the battle against leukemia helps children living with cancer and their families. Our goal is to make sure children battling cancer know they are not alone. For more information please visit www.terramedalliance.org. Email at contact@terramedalliance.org
Should I die my hair back to my natual color med. brown?
Ok I am bleach blond with a brown under layer and I like it but I can't remember what I look like with my natual color....Should I die my hair back or do something diffrent. I love to do different things with my hair. Give me some ideas!!!
go natural it'll amazzzzing !! btw second picture, your hilarious ! 
:)
ebba grön - die mauer
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